Prof. Harats will host a panel that will also include Dr. Andrew Brenner, from the University of Texas Health Science Center at San Antonio, Dr. Yael Cohen, MD, VP Clinical Development at VBL Therapeutics and Dr. Deborah Blumenthal from the Tel‐Aviv Sourasky Medical Center. The panel is expected to highlight VBL therapeutics' proprietary Vascular Targeting System (VTS™) platform that has yielded VB‐111, a first‐in‐class, highly‐targeted, novel anti‐angiogenic biological agent for the treatment of cancer.
VB-111 is given as a simple IV infusion and acts like a "biological knife" to cut the vasculature feeding the tumor. With promising Phase 2 clinical data showing encouraging effects on Overall Survival in recurrent Glioblastoma Multiforme (rGBM) and multiple cases of objective response, VBL is planning ahead towards a VB-111 pivotal trial in rGBM. Orphan drug status for GBM was awarded to VB-111 in the US and in Europe. VB-111 is also evaluated in multi-dose Phase 2 clinical trials for differentiated thyroid cancer and ovarian cancer.
VB-111 is a novel IV-administered anti angiogenic agent that utilizes VTS™, VBL’s proprietary platform technology to target endothelial cells in the tumor vasculature for cancer therapy. VB-111 contains a non-replicating adenovector, a proprietary modified murine pre-proendothelin promoter (PPE-1-3x) and a Fas-Chimera transgene. The modified promoter specifically targets the expression of the Fas-Chimera transgene to angiogenic tumor blood vessels, leading to their apoptosis. VB-111 is the first agent based on transcriptional targeting of tumor endothelium to be assessed in a clinical trial.
VB-111 has successfully completed a Phase I/II “all comers” clinical trial, which demonstrated multiple cases of objective tumor response and disease control and excellent safety and tolerability. VB-111 has been advanced into tumor specific, repeat-dose trials in glioblastoma multiforme, thyroid cancer and ovarian cancer.